Tagipmet XR Tablets 100mg-1000mg

Product Name: Tagipmet XR Tablets 100mg-1000mg

 Product Form: Tablets

 Pack Size: 14's

Manufactured By: Highnoon Laboratories

Used For:

• Metformin and Sitagliptin are commonly prescribed together to treat type 2 diabetes. This combination helps control blood sugar levels by addressing different mechanisms:
  • Metformin works primarily by reducing liver glucose production and improving insulin sensitivity in muscle and fat cells, which helps the body better use the insulin it produces.
  • Sitagliptin is a DPP-4 inhibitor that works by increasing the levels of incretin hormones, which help regulate insulin release and reduce glucose production by the liver.

Side Effects:

• Common Side Effects:
  • Metformin: Diarrhea, nausea, stomach upset, and weight loss.
  • Sitagliptin: Upper respiratory tract infections, sore throat, headache, and diarrhea.
• Serious Side Effects:
  • Metformin: Rarely, lactic acidosis (a life-threatening buildup of lactic acid in the body), kidney problems, and vitamin B12 deficiency with long-term use.
  • Sitagliptin: Pancreatitis (inflammation of the pancreas), severe allergic reactions (rash, swelling, difficulty breathing), and joint pain.

Precautions:

• Kidney Function: Both medications are metabolized by the kidneys, so kidney function should be monitored regularly, especially with metformin, which can cause lactic acidosis in patients with impaired kidney function.
  • Metformin should be used with caution or avoided in patients with significant kidney disease.
  • Sitagliptin may require dose adjustments for patients with mild to moderate kidney impairment.
• Liver Function: Metformin should be used with caution in patients with liver disease or excessive alcohol use, as this increases the risk of lactic acidosis.
• Pancreatitis Risk: Sitagliptin has been associated with a small increased risk of pancreatitis, and should be discontinued if symptoms of severe abdominal pain occur.
• Hypoglycemia: While metformin typically does not cause low blood sugar on its own, when combined with other diabetes medications, the risk of hypoglycemia (low blood sugar) may increase. Sitagliptin, when used with insulin or sulfonylureas, can also increase this risk.
• Pregnancy and Breastfeeding: Both medications are generally considered safe during pregnancy (Category B for metformin, Category C for sitagliptin). However, they should be used only under medical supervision, especially during pregnancy and breastfeeding.