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SPECIFICATION
Requires Prescription (YES/NO)
Yes
Generics
Ciprofloxacin HCl
Used For
Bacterial Infection
How it works
It acts via inhibition of bacterial DNA gyrase (topoisomerase, which is essential in the reproduction of bacterial DNA), ultimately resulting in interference with DNA function. Ciprofloxacin is highly active against a wide range of Gram-positive and Gram-negative organisms and has shown activity against some anaerobes.
USAGE AND SAFETY
Dosage
Ciprofloxacin HCl
Side Effects
Nausea, Diarrhoea , Mycotic superinfections, Eosinophilia, Anorexia, Psychomotor hyperactivity / agitation, Headache, Dizziness, Sleep disorders, Taste disorders, Vomiting, Gastrointestinal and abdominal pains, Dyspepsia, Flatulence, Increase in transaminases, Increased bilirubin, Rash, Pruritus, Urticaria, Musculoskeletal pain (e.g. extremity pain, back pain, chest pain), Arthralgia, Renal impairment, Asthenia, Fever, Increase in blood alkaline phosphatase.
Drug Interactions
Theophylline, clozapine, tacrine, ropinirole, tizanidine, duloxetine , Chelation complex formulation like , calcium, magnesium, aluminum or iron), polymeric phosphate binders (e.g., sevelamer), sucralfate or antacids and highly buffered drugs (e.g., didanosine ) , caffeine or pentoxifylline (oxpentifylline) , Phenytoin , Glyburide/Glibenclimide , Warfarin , Probencid , Methotrexate , Metoclopramide , Omeprazole , Cyclosporin , Sildenafil.
Indication
It is used to treat : • Lower respiratory tract infections due to Gram-negative bacteria• Acute exacerbation of chronic sinusitis especially if these are caused by Gram-negative bacteria• Urinary tract infections• Genital tract infections
When not to Use
Ciprofloxacin is contraindicated in patients with a history of hypersensitivity to ciprofloxacin, any member of the quinolone class of antimicrobial agents or any of the product components. - Concomitant administration with tizanidine is contraindicated.
PRECAUTIONS
Precaution
Cases of hepatic necrosis and life-threatening hepatic failure have been reported with ciprofloxacin. In the event of any signs and symptoms of hepatic disease (such as anorexia, jaundice, dark urine, pruritus, or tender abdomen), treatment should be discontinued.
WARNINGS
Warning 1
Hypersensitivity and allergic reactions, including anaphylaxis and anaphylactoid reactions, may occur following a single dose and may be life-threatening.If such reaction occurs, ciprofloxacin should be discontinued and an adequate medical treatment is required.
Warning 2
Ciprofloxacin should be discontinued in patients experiencing symptoms of neuropathy, including pain, burning, tingling, numbness, and/or weakness in order to prevent the development of an irreversible condition.
Warning 3
Patients with a family history of actual defects in glucose-6-phosphate dehydrogenase activity are prone to hemolytic reactions with quinolones, and so ciprofloxacin should be used with caution in these patients.
ADDITIONAL INFORMATION
Pregnancy category
Always consult your physician before using any medicine.
Storage (YES/NO)
Store this medicine at room temperature, away from direct light and heat.
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