Ponaxen Tablets 15mg

Product Description

Product Name: Ponaxen Tablets 15mg

Product Form: Tablets

Pack Size: 30's

Manufactured By: Everest Pharmaceuticals

Used For:

1. Chronic Myeloid Leukemia (CML):
   • Indicated for adults with chronic, accelerated, or blast-phase CML who are resistant or intolerant to other TKIs or have the T315I mutation.
2. Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia (Ph+ ALL):
   • Indicated for adults with Ph+ ALL resistant or intolerant to prior TKI therapy.

Side Effects:

1. Common Side Effects:

   • Fatigue
   • Rash or dry skin
   • Nausea
   • Constipation or diarrhea
   • Abdominal pain
   • Joint or muscle pain

2. Serious Side Effects:

   • Cardiovascular Events: High risk of blood clots, heart attack, or stroke.
   • Hypertension: Elevated blood pressure is common and must be managed.
   • Liver Toxicity: May cause elevations in liver enzymes or severe liver damage.
   • Pancreatitis: Increased levels of pancreatic enzymes.
   • Bleeding: Risk of severe bleeding in some patients.
   • Myelosuppression: Low blood cell counts (anemia, neutropenia, thrombocytopenia).

Precautions:

1. Before Starting Ponatinib:

   • Inform your doctor about any history of heart disease, high blood pressure, diabetes, or blood clot disorders.
   • Baseline testing for heart function, liver function, and pancreatic enzymes is essential.

2. During Treatment:

   • Regular monitoring of blood pressure, liver function, pancreatic enzymes, and blood counts.
   • Take steps to manage high blood pressure or cholesterol levels to reduce cardiovascular risks.
   • Avoid use in pregnancy or breastfeeding. Effective contraception is advised during and after treatment (for 3 weeks post-treatment).

3. Lifestyle Modifications:

   • Maintain a heart-healthy diet and avoid smoking.
   • Stay hydrated and avoid excessive alcohol consumption to reduce liver strain.

4. When to Contact Your Doctor:

   • Signs of heart or blood clot issues (e.g., chest pain, sudden weakness, or numbness).
   • Persistent abdominal pain or severe nausea.
   • Unusual bleeding or bruising.
   • Symptoms of infection (e.g., fever, chills).