Osicent Tablets 80mg

Product Description

Product Name: Osicent Tablets 80mg

Product Form: Tablets

Pack Size: 10's

Manufactured By: Incepta Pharma

Used For:

1. Non-Small Cell Lung Cancer (NSCLC):
   • Approved for first-line treatment of NSCLC with EGFR exon 19 deletions or exon 21 (L858R) substitution mutations.
   • Treatment of NSCLC with EGFR T790M mutation following progression on prior EGFR-targeted therapy.

Side Effects:

1. Common Side Effects:

   • Diarrhea
   • Rash (acne-like or dry skin)
   • Nail changes (brittle, tender nails)
   • Mouth sores (stomatitis)
   • Fatigue
   • Decreased appetite

2. Serious Side Effects:

   • Interstitial lung disease (ILD)/Pneumonitis: Can cause severe or life-threatening lung inflammation.
   • Cardiac toxicity: Risk of QT prolongation or heart failure.
   • Severe skin reactions: Such as Stevens-Johnson Syndrome.
   • Eye disorders: Keratitis or blurred vision.
   • Myelosuppression: Low white blood cell, platelet, or red blood cell counts.

Precautions:

1. Before Starting Osimertinib:

   • Ensure genetic testing confirms the presence of EGFR mutations.
   • Inform your healthcare provider about any heart conditions, lung issues, or liver problems.

2. During Treatment:

   • Regular monitoring of liver function, heart function (e.g., ECG), and blood cell counts.
   • Avoid pregnancy during treatment and for at least 6 weeks after the last dose (for females). Males with partners of childbearing potential should use contraception during treatment and for 4 months after.
   • Avoid grapefruit or grapefruit juice, as it may interact with osimertinib metabolism.

3. When to Contact Your Doctor:

   • New or worsening respiratory symptoms (e.g., shortness of breath, cough).
   • Signs of heart problems (e.g., swelling in ankles, fatigue, irregular heartbeat).
   • Persistent diarrhea or skin reactions.
   • Vision changes.