Neo-Pyrolate Injection

Product Description

Product Name: Neo-Pyrolate Injection

Product Form: Injection

Pack Size: 1ml

Manufactured By: Brookes Pharma

Used For:

1. Pre-Anesthetic Use:
   • Neo-Pyrolate is commonly administered before surgery to reduce salivary, gastric, and respiratory secretions. This helps to prevent complications during and after surgery, such as aspiration (inhalation of secretions into the lungs).
2. To Reverse Muscle Relaxants:
   • It is used in combination with neostigmine or other drugs to reverse the effects of muscle relaxants (used during surgery) after a procedure.
3. Peptic Ulcer Treatment:
   • Glycopyrrolate can be used in the management of peptic ulcers to reduce gastric acid secretion, which helps in healing ulcers.
4. Excessive Salivation:
   • It is sometimes used to treat conditions like sialorrhea (excessive salivation), often seen in patients with neurological disorders.
5. Cardiovascular Stabilization:
   • Neo-Pyrolate may be used to prevent bradycardia (slow heart rate) during surgery, particularly when anesthetics or other drugs that slow heart rate are being used.

Side Effects:

As with any medication, glycopyrrolate (Neo-Pyrolate) can cause side effects.

• Common Side Effects:

  • Dry mouth
  • Blurred vision
  • Constipation
  • Urinary retention (difficulty passing urine)
  • Drowsiness or dizziness
  • Difficulty swallowing (due to reduced salivation)

• Serious Side Effects:

  • Rapid or Irregular Heartbeat: Glycopyrrolate can cause heart issues such as tachycardia or arrhythmias, especially in patients with underlying heart conditions.
  • Severe Allergic Reactions: Symptoms may include rash, itching, swelling, dizziness, or difficulty breathing.
  • Confusion or Disorientation: Although rare, glycopyrrolate can cause cognitive issues in some patients, especially the elderly.
  • Severe Heat Intolerance: Since it reduces sweating, there’s an increased risk of heatstroke in hot environments.

Precautions:

1. Pre-existing Medical Conditions:

   • Glaucoma: Glycopyrrolate can worsen narrow-angle glaucoma.
   • Heart Disease: Patients with coronary artery disease, congestive heart failure, or arrhythmias should use glycopyrrolate with caution.
   • Bowel Obstruction: It may worsen conditions like paralytic ileus or bowel obstruction.
   • Prostate Enlargement (BPH): It may aggravate urinary retention in men with enlarged prostates.

2. Pregnancy and Breastfeeding:

   • Neo-Pyrolate should only be used during pregnancy if clearly needed, as its safety profile in pregnant women has not been fully established.
   • It is unknown whether glycopyrrolate passes into breast milk, so caution is advised for breastfeeding women.

3. Heat and Physical Activity:

   • Glycopyrrolate reduces sweating, which can increase the risk of heat exhaustion or heat stroke. Avoid prolonged exposure to hot environments and stay hydrated.

4. Drug Interactions:

   • Other Anticholinergics: Combining glycopyrrolate with other anticholinergic drugs (e.g., atropine) can amplify side effects like dry mouth, blurred vision, and constipation.
   • Antacids: May reduce the absorption of glycopyrrolate.
   • Sedatives and Antihistamines: Combining glycopyrrolate with sedatives, tranquilizers, or antihistamines can increase drowsiness.