Used For:
Metformin and empagliflozin are used together to manage type 2 diabetes. Metformin works by reducing glucose production in the liver and improving insulin sensitivity, which helps control blood sugar levels. Empagliflozin is an SGLT2 inhibitor that works by preventing the kidneys from reabsorbing glucose, allowing excess glucose to be excreted in urine. Together, they help control blood sugar levels and reduce the risk of complications related to diabetes, such as kidney disease and heart failure.
Side Effects:
Common side effects of this combination include nausea, diarrhea, and abdominal discomfort, particularly with metformin. Empagliflozin may cause urinary tract infections, increased urination, dehydration, and yeast infections. Serious side effects include lactic acidosis (a rare but severe condition caused by metformin), kidney problems, and diabetic ketoacidosis (mainly with empagliflozin).
Precautions:
This combination should be used with caution in patients with kidney or liver problems, as both metformin and empagliflozin are cleared through these organs. Metformin should be avoided in people with severe kidney dysfunction, and empagliflozin may require dose adjustments in those with moderate kidney impairment. It is important to monitor kidney function during treatment. Pregnant or breastfeeding women should consult their doctor before using this combination. This medication should also be used with caution in individuals who are dehydrated or at risk for dehydration.