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Amarant Pharmaceuticals

Amprexa-F Capsules 6mg/25mg

Generic Name: Olanzapine, Fluoxetine

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Rs.244.00 PKR inc. VAT

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Product Description

Product Name: Amprexa-F Capsules 6mg/25mg

Product Form: Capsules

Pack Size: 6mg/25mg

Manufactured By: Amarant Pharmaceuticals

Used For:

  • Treatment-Resistant Depression: Effective for cases of major depressive disorder (MDD) that do not respond to other antidepressants alone.
  • Bipolar Depression: Approved for the depressive episodes of bipolar disorder, particularly where other mood stabilizers may be less effective.
  • Schizoaffective Disorder (Off-Label): May be used to treat mood symptoms associated with schizoaffective disorder, although not formally approved for this use.

Side Effects:

  • Common Side Effects:
    • Olanzapine: Weight gain, drowsiness, dry mouth, constipation, and increased appetite.
    • Fluoxetine: Nausea, headache, insomnia, sexual dysfunction, and anxiety, particularly when starting the medication.
  • Less Common but Serious Side Effects:
    • Metabolic Changes (Olanzapine): Increased blood glucose, cholesterol, and triglycerides, which can lead to diabetes or metabolic syndrome.
    • Serotonin Syndrome (Fluoxetine): A rare but serious condition caused by excess serotonin, leading to agitation, confusion, rapid heart rate, and high blood pressure.
    • Neuroleptic Malignant Syndrome (NMS) (Olanzapine): A rare, potentially life-threatening reaction with symptoms like muscle rigidity, fever, and altered mental status.
    • Suicidal Thoughts (Fluoxetine): Like all SSRIs, fluoxetine may increase the risk of suicidal thinking in adolescents and young adults.

Precautions:

  • Metabolic Monitoring: Due to olanzapine’s potential for metabolic side effects, regular monitoring of weight, blood glucose, and cholesterol is essential.
  • Avoid in Elderly Dementia Patients: Olanzapine increases the risk of death in elderly dementia patients and should be used cautiously in this population.
  • Avoid Alcohol: Alcohol can intensify side effects such as drowsiness and dizziness.
  • Tapering: Fluoxetine, if stopped, should be tapered to avoid withdrawal symptoms, although it has a longer half-life than many SSRIs, making withdrawal milder.
  • Pregnancy and Breastfeeding: This combination is typically avoided in pregnancy and breastfeeding unless benefits clearly outweigh risks, as both medications can affect the fetus or infant.